APOE and age-related macular degeneration: Third, genetic association studies have identified risk variants in genes involved in lipid metabolism and in the transfer of lipids among lipoproteins, such as hepatic lipase C (LIPC), lipoprotein lipase (LPL), cholesterol ester transferase (CETP), ABC-binding cassettes A1 (ABCA1), and apolipoprotein E (APOE), all of which have been shown to influence the course of AMD pathobiology [35–37].