In our study, the lipid biomarkers LDL-C (OR = 0.90, 95% CI: 0.85–0.96, P = 2.03 × 10−3) and ApoB (OR = 0.52, 95% CI: 0.38–0.72, P = 6.60 × 10−5) play protective roles in the development of early AMD. Here, APOB is linked to age-related macular degeneration.