APOB and age-related macular degeneration: Estimates from the IVW and weighted mode methods indicate that a higher ApoB level is significantly associated with decreased risk of early AMD (IVW: OR = 0.52, P = 6.60 × 10−5; weighted mode: OR = 0.56, P = 1.85 × 10−3), although these results were not significant after Bonferroni correction (Table 1).