In addition, levels of ApoA were also found to be positively associated with risk of early AMD (OR = 2.04, 95% CI: 1.50–2.77, P = 6.27 × 10−6) (Figs. 1B and 2), and these estimates were supported by the other three MR methods (Table 1). The gene discussed is APOA1; the disease is age-related macular degeneration.