The results showed upregulation in DDR pathways including HRR, MMR, nucleotide excision repair (NER), Fanconi anemia pathway (FA), translesion DNA synthesis (TLS), nonhomologous end-joining (NHEJ), and checkpoint factors (CPF), demonstrating a compensatory activation in DDR pathways due to a SETD2 mutation (Figure S1). The gene discussed is NR5A2; the disease is Fanconi anemia.