GATA1 and acute myeloid leukemia: The human hematopoietic system is a hierarchal system which is tightly regulated by dynamic changes in chromatin accessibility20,21 and transcription factors that dictate cell lineages22 Similar to normal hematopoiesis, the rewiring of cellular transitions in therapy-resistant AML malignant cells was afforded by dynamic dependency on canonical transcriptional regulators of lineage transitions such as GATA1, RUNX, and POU2F279, and regulators of cellular transformation such as transcription factor AP-180.