PITX2 and alopecia: For example, paired like homeodomain 2 (Pitx2)24, Nk homeobox 3 (Nkx2-3)25, and ISL LIM homeobox 1 (Isl1)26 are implicated in enamel epithelial homeostasis7 while transcription factors and signaling genes including HR lysine demethylase and nuclear receptor corepressor (Hr also called hairless) and Ras and Rab interactor 2 (Rin2) are important in controlling hair differentiation as mutations in these genes cause alopecia (hair loss)27,28.