Hematopoietic progenitors or lymphocyte subsets express low levels of ALDH, predisposing these cells to have a low inactivation rate and to be more sensitive to the bioactivated compound; therefore, enhanced hematologic toxicity is expected to emerge16,79,80 as it was found in neuroblastoma patients (Supplementary Table 2). The gene discussed is LDHA; the disease is neuroblastoma.