CD36 and fatty liver disease: Upregulation of CD36 membrane protein positively correlates with elevated hepatocyte uptake of fatty acids and hepatic steatosis in models of NAFLD originating in adulthood.14,19,20 Conversely, hepatocyte-specific deletion of CD36 attenuates steatosis in rodent models of adult NAFLD.22,23,33 Our previous study and the current data further support a role of CD36 in NAFLD development, as both showed a strong correlation between hepatic Cd36 mRNA and protein levels with TG content, as well as increased steatosis.