Here, the fibroblast-endothelial network remained the driver of the obesity-associated changes in the TME intercellular communication, except that the crosstalk occurred largely amongst themselves, instead of also involving cancer cells or mast cells as in the NST ER+/HER2− tumors (Fig. 6f–g). The gene discussed is ERBB2; the disease is obesity due to melanocortin 4 receptor deficiency.