Other genes that are involved in cell proliferation, migration, invasion, inflammation, and cellular metabolism, and might be relevant for further investigation, e.g., mucins (MUC1, MUCL1, MUC5B)45,46, inflammatory signaling factors (FOS, JUNB, IL32)47,48, insulin receptor INSR, lipid transporter APOD49, were also found to be overexpressed in NST ER+/HER2− cancer cells from obese patients (Fig. 5a). The gene discussed is ESR1; the disease is cancer.