NLRP3 and familial dilated cardiomyopathy: The increase in ROS and NLR family pyrin domain-containing 3 (NLRP3) inflammasomes in cardiomyocytes induced by persistent high glucose can also cause inflammation, cardiomyocyte apoptosis, and myocardial fibrosis and exacerbate the development of DCM [31, 43, 44].