A gene profile-based prevention strategy can be derived as follows: for populations in North China where a higher incidence rate of cardiovascular and cerebrovascular diseases has been observed39, regularly enhancing folate intake to lower homocysteine levels among individuals with MTHFR 677A allele and possibly other populations with similar genetic and environmental conditions may be an effective prevention strategy to reduce the disease burden. The gene discussed is MTHFR; the disease is cerebrovascular disorder.