Almost all loci were present in the intergenic region except for two intronic SNVs: rs200364330 at PDE5A which regulates intracellular concentrations of cyclic nucleotides and plays a role in smooth muscle relaxation in the cardiovascular system56 and rs938277067 at ZNF804A, which was associated with schizophrenia and bipolar disorders56. This evidence concerns the gene PDE5A and schizophrenia.