MPL and Familial prostate cancer: Six of the 19 newly identified signals have functions according to the GWAS catalog (Supplementary Tables S13 and S14): the MPL locus is associated with myelofibrosis and amegakaryocytic thrombocytopenia; the SNX25 locus is associated with hair color measurement; the SLC52A3-FAM110A locus is associated with prostate cancer; the TCN2 locus is associated with type 2 diabetes; the TBC1D1-LINC01258 locus is associated with heel bone mineral density; and the CTNNA1 locus was associated with susceptibility to digestive cancer.