To investigate whether JUNB regulates the secretion of MCSF induced by ZIC2 overexpression, we detected the expression of MCSF in NPC cells treated with the JUNB-specific siRNA and inhibitor T5224 and found that the expression of MCSF was significantly decreased by ELISA (Fig. 5A), suggesting JUNB is involved in MCSF secretion in NPC cells. Here, JUNB is linked to nasopharyngeal carcinoma.