Mechanistically, previous studies have shown that ZIC2 is highly expressed in clear cell renal cell carcinoma (ccRCC) and promotes the proliferation and migration of ccRCC by regulating the expression of the downstream target gene Runx2 and the ZIC2/Runx2/NOLC1 signaling axis [35]. The gene discussed is NOLC1; the disease is nonpapillary renal cell carcinoma.