ZIC2 and nasopharyngeal carcinoma: Moreover, we found that overexpression of ZIC2 in NPC cells significantly increased the expression of the M2 phenotype cytokines IL-13 and related surface marker CD206 but decreased the expression of the M1 phenotype cytokines IFN-γ and related surface marker CD86 in THP-1 cells, as shown by RT-PCR (Supplemental Fig. 1C).