To elucidate the mechanism of STAG2-deficient thyroid cancer cells being more sensitive to glutamine deprivation, we first determined the impact of STAG2 knockdown on the expression of glutamine transporter SLC1A5 and glutaminases GLS and GLS2, which are essential for glutamine metabolism [19–21]. This evidence concerns the gene SLC1A5 and thyroid gland carcinoma.