In addition, our data also indicated that STAG2 knockdown in BRAF-mutant thyroid cancer cells led to an elevated ROS level and a declined GSH/GSSH ratio when glutamine deprivation or treated with glutaminase inhibitor, meaning that the cells are less resistant to oxidative stress damage due to their reduced ability to use glutamine [25, 26]. The gene discussed is GLS; the disease is thyroid cancer.