Recent studies have unveiled that SCLC is not a homogeneous disease and is instead comprised of four distinct molecular subtypes based on expression of lineage-defining transcription factors: ASCL1 (SCLC-A), NEUROD1 (SCLC-N), POU2F3 (SCLC-P), or YAP1 (SCLC-Y)4. This evidence concerns the gene ASCL1 and small cell lung carcinoma.