While additional studies need to be conducted to further understand the role of SCLC subtype in the response to p53 in human SCLC, our findings suggest that intertumoral heterogeneity in both mouse and human SCLC influences the tumor suppressive programs induced by p53 with at least a subset of human SCLC vulnerable to p53-mediated, cyclophilin-dependent cell death. This evidence concerns the gene TP53 and neoplasm.