While p53 interactions with cyclophilin D were minimally present in both Type V and Type D SCLC (Supplementary Fig. 12), we could not establish prominent p53 localization to the mitochondria or detect evidence for a unique impact on mitochondria physiology after p53 restoration in Type D SCLC cell lines (Supplementary Fig. 13). Here, PPID is linked to small cell lung carcinoma.