Human SCLC is a highly heterogeneous disease that has recently been stratified into four molecular subtypes based on expression of lineage defining factors: ASCL1 (SCLC-A), NEUROD1 (SCLC-N), YAP1 (SCLC-Y), POU2F3 (SCLC-P)4. The gene discussed is POU2F3; the disease is small cell lung carcinoma.