A query of human AD versus control post‐mortem brain single cell study revealed altered expression of many genes involved in myelin lipid synthesis and metabolism in OLGs of AD subjects55, 57 (e.g., upregulation of Plpp2 presumably leading to reduced levels of phosphatidic acid, a key substrate for all phospholipid biosynthesis, and downregulation of ABCA2, which is known to affect sphingolipid metabolism58). This evidence concerns the gene ABCA2 and Alzheimer disease.