Further, we explored spinal cord–peripheral consequences and related molecular mechanisms of adult‐onset ST deficiency using a mouse model of myelinating cell‐specific depletion (driven by Plp1‐CreERT) of cerebroside (CBS) sulfotransferase (CST, a.k.a. Gal3st1) gene, which codes for the final‐step enzyme that catalyses ST biosynthesis. Here, GAL3ST1 is linked to recessive X-linked ichthyosis.