Interestingly, the changes of lipid profiles induced by ST loss in mice (Figure 3C), including decrease of ST, PA, PS, PE, AC, CBS, TAG and FA, as well as increase of PG (Figure 3C and Figure S2B), were highly consistent to those in human AD spinal cord versus control (Figure 1F,G), suggesting that ST plays a critical role in maintaining spinal cord lipid homeostasis. Here, CBS is linked to Alzheimer disease.