RET and neoplasm: Rearranged during transfection (RET) gene fusions occur in 0.7% to 2% in lung cancer and 1% to 2% in non-small cell lung cancer (NSCLC).[1,2] Located on chromosome 10q11.2, RET encodes a transmembrane tyrosine kinase that could activate pivotal tumor-promoting signaling pathways such as PI3K/Akt and rat sarcoma/mitogen-activated protein kinase.