Molecular testing with a targeted panel of 8 lung cancer-associated driver genes (Burning Rock Biotech, Guangzhou, China) detected a novel PIBF1-RET (P16:R12) fusion (abundance 10.3%), which putatively encodes a gene in which the first 16 exons of PIBF1 was concatenated to RET exon 13 and its downstream sequence, retaining the RET kinase domain (Fig. 2A and B). The gene discussed is RET; the disease is lung cancer.