Neurofibromatosis type I is a complex autosomal dominant disorder caused by germline mutations in the NF1 tumor suppressor gene.[1] The incidence varies substantial between countries, with a global average of approximately 1 in 3000.[2] The clinical manifestations, types of complications, and speed and degree of progression of the disease vary from person to person and gradually develop throughout life. The gene discussed is NF1; the disease is neurofibromatosis type 1.