CXCL8 and gout: IL-17 is mainly produced by T helper 17 cells (Th17) and acts as a pro-inflammatory factor that mediates inflammation.[34] A study showed that serum levels of IL-17 in GA patients were significantly elevated during the early onset of gout symptoms and then gradually decreased as the symptoms decreased.[35] Moreover, IL-17 cannot only exist as a pro-inflammatory factor but also stimulate various cells, such as epithelial and endothelial cells, to produce inflammatory factors that produce cytokines such as interleukin-6 and interleukin-8, leading to an inflammatory response.