Previous studies have shown that luteolin can reduce serum uric acid levels in hyperuricemic mice by inhibiting the activity of hepatic xanthine oxidase and significantly reducing MSU-induced paw edema and IL-1β levels, making it a promising drug for the treatment of GA.[32] In addition, beta-sitosterol has been shown to reduce MSU-induced paw edema in mice.[33] There are no relevant studies on physovenine for the treatment of gout, which suggests that it could also be a candidate for subsequent experimental studies. The gene discussed is XDH; the disease is gout.