IL1B and gout: In vitro and in vivo studies have confirmed that interleukin-1-beta (IL-1β) plays an essential role in the formation and destruction of gout,[10] and when the upstream pathway of IL-1β production is blocked, the level of IL-1β can be effectively lowered, alleviating gout attacks and reducing pain in patients.[11] IL-1β is a critical cytokines in the acute inflammatory response to gout and can cause an inflammatory response.