HTR3A and delirium: Finally, it is worth mentioning that 5-HT3 antagonists and anti-dopamine drug use may lead to a prolonged QT interval, while anticholinergic drugs, antihistamine drugs, and dexamethasone may lead to delirium in high-risk patients.[44,45] At present, there is no evidence that aprepitant has significant side effects.[2,40] Therefore, aprepitant is a potential alternative to other drugs such as ondansetron, dexamethasone, romansetron, and palonosetron that have contraindications.