SMAD4 and non-small cell lung carcinoma: In our result, our aim of this article is to investigate the relationship between SMAD4 expression and the clinicopathological parameters and prognosis of NSCLC patients, and we found that SMAD4 expression was associated with TNM stage (stages I-II and stages III-IV, OR = 0.238, 95% CI: 0.156–0.362, P = .000) in NSCLC patients.