NFE2L2 and Hepatic fibrosis: Experiments demonstrated that quercetin might inhibit liver inflammation through regulating NF-κB/TLR/ NLRP3 and reducing PI3K/Nrf2-mediated oxidative stress, and improve hepatic fibrosis by inhibiting HSC activation and regulating pro-fibrogenic/anti-fibrogenic molecules balance.[31–33] Curcumin, the principal curcuminoid of CL, has been reported to show antitumor, antioxidant, and anti-inflammatory properties both in in vitro and in vivo systems.