As mentioned above, both curcumin and demethoxycurcumin were strongly bound to MAPK1, EGFR, and SRC, which indicated that curcumin and demethoxycurcumin might be the core components against hepatic fibrosis, and MAPK1, EGFR, and SRC might be the core targets. Here, MAPK1 is linked to Hepatic fibrosis.