The role of HIF-1 in the development of hepatic fibrosis has been clearly identified by experiments, which closely interacts with VEGF, PI3K/Akt, MAPK, TGF-β and NF-kB signaling pathways, and plays an important role in HSC activation and ECM synthetization.[36,37]. This evidence concerns the gene TGFB1 and Hepatic fibrosis.