The role of HIF-1 in the development of hepatic fibrosis has been clearly identified by experiments, which closely interacts with VEGF, PI3K/Akt, MAPK, TGF-β and NF-kB signaling pathways, and plays an important role in HSC activation and ECM synthetization.[36,37]. The gene discussed is PIK3CA; the disease is Hepatic fibrosis.