Accumulating data shows that curcumin inhibits HSC activation by blocking leptin signaling, regulating intracellular glucose and its derivatives and modulating lipid metabolism, as well as balancing formation and degradation of ECM, in combating liver fibrogenesis.[34] Demethoxycurcumin is a naturally occurring curcumin analogue, and there have been few studies on the treatment of liver diseases with demethoxycurcumin until now.[35] Notably, our molecular docking results showed that both curcumin and demethoxycurcumin strongly bound to MAPK1, EGFR and SRC. This evidence concerns the gene MAPK1 and liver disorder.