As mentioned above, both curcumin and demethoxycurcumin were strongly bound to MAPK1, EGFR, and SRC, which indicated that curcumin and demethoxycurcumin might be the core components against hepatic fibrosis, and MAPK1, EGFR, and SRC might be the core targets. The gene discussed is EGFR; the disease is Hepatic fibrosis.