Numerous factors contribute to fatigue in IBD patients, such as disease activity index [4–6], psychosomatic stresses [6] and mental disorders like anxiety and depression [2,4], IBD-related medications such as Azathioprine, Anti-TNF-α [7], Corticosteroids, and Methotrexate [8,9], and alterations in the gut-brain axis [10]. The gene discussed is TNF; the disease is inflammatory bowel disease.