CRP has been shown to be one of the only sufficiently accurate biomarkers that could safely and effectively reduce the prescribing of antibiotics; in a study in Beijing in 2015, CRP was as effective as procalcitonin (PCT) in predicting bacteremia, and more effective at predicting severe sepsis [16]; while in a study in Iran in 2017, it performed better than PCT and WBC at predicting bacterial meningitis [17]. This evidence concerns the gene CRP and bacterial infectious disease with sepsis.