Deleterious de novo variants in known genes (MYH7, TNNI3, TPM1, TNNT2, TTN, DES, RYR2 and NF1) were identified in 11 (12%) pediatric probands but no de novo variants were identified in adult-onset cardiomyopathy (OR 8.3; p = 0.042) although the analysis was limited by the relatively small number of complete trio data. The gene discussed is MYH7; the disease is cardiomyopathy.