In addition, analysis from the DepMap website using CRISPR-Cas9 technology to screen for the necessity of various genes for tumors found that multiple myeloma, hematopoietic cells, and lymphocytes appear to be particularly dependent on CARM1 (Multiple Myeloma (2.2e-17) n = 21, Haematopoietic And Lymphoid (1.3e-24) n = 118, Lymphocyte (2.0e-07) n = 37) (Fig. 1b). This evidence concerns the gene CARM1 and AL amyloidosis.