CDKN2A and neoplasm: Multivariate analysis indicated that poor differentiation (multivariate OR = 3.82, 95% CI = 1.41–12.2, P = 0.008) and CDKN2A/p16 alteration (multivariate OR = 2.06, 95% CI = 1.08–4.02, P = 0.046) were independent predictors of a low tumor-stromal collagen amount in PDAC (Table 2).