After adding 740Y-P, PI3K agonist, the expression of SBEM protein in cancer cells of miR-186-5p mimic + 740Y-P group was significantly decreased than the miR-186-5p mimic NC + 740Y-P group, while the protein levels of p-PI3K, p-AKT, MMP1, MMP3 and MMP9 were not significantly changed. The gene discussed is MMP3; the disease is cancer.