For example, miR-140-5p inhibits angiogenesis and invasion of breast cancer cells by regulating VEGF-A [13] and miR-204-5p lowers the proliferation and migration of breast cancer cells through remodeling the tumor immune microenvironment [14], indicating that the abnormal mi RNA in breast cancer cells not only affects the occurrence and progress of breast cancer, and maybe an effective biomarker and target for breast cancer metastasis evaluation and biotherapy [15]. The gene discussed is VEGFA; the disease is breast cancer.