INS and type 2 diabetes mellitus: When functioningcorrectly, IAPP, together with insulin, contributes to glycaemic control.IAPP and insulin are synthesized and stored together in pancreaticβ-cells, but when IAPP aggregates in the extracellular spaceof the islets of Langerhans, amyloid-induced apoptosis of β-cellsmay occur.62 In 95% of T2D patients, IAPPis found as extracellular amyloid deposits,63−65 which formthrough surface-catalyzed secondary nucleation.66