Though how autophagy activation augments Linc00942 for RNautophagic degradation via p62 needs further investigation, this newly defined methylation cascade could act in complement with another cascade from histone methylation to DNA methylation to reform the DNA methylation landscape in response to the dynamic environment, which confers the adaption plasticity, such as chemoresistance to the host cancer cells. Here, LINC00942 is linked to cancer.