Long noncoding RNA (lncRNA) small nucleolar RNA host gene 16(SNHG16), mediated by exosomes, could sponge miR-16-5p to upregulate SMAD family member 5(SMAD5), resulting in cluster of differentiation 73(CD73) upregulation in Vδ1 T cells, promoting the immunosuppressive regulations in breast cancer [7]. The gene discussed is SMAD5; the disease is breast cancer.