EGF and adenoviridae infectious disease: In the late stage of adenovirus infection, alveolar epithelial tissue begins to repair itself when macrophages accumulate in large numbers, secreting piles of growth factors, including epidermal growth factor (EGF) and transforming growth factor (TGF), among which TGF-β is a pleiotropic kind of cytokine, essential for many cellular activities, such as proliferation, differentiation, and adhesion, and is the basic pathogenesis of pulmonary tissue fibrosis (56, 57).