They are also used in combination with gemcitabine, the CDK4/6-inhibitor ribociclib, the BRAF-inhibitor trametinib or the cytokine filgrastim for treatment of brain tumors (like astrocytoma, meningioma, ependymoma) in children and young adults (NCT03434262). The gene discussed is CDK4; the disease is astrocytoma (excluding glioblastoma).