Purinergic receptors, including P1 receptors, P2X and P2Y receptors, are widely expressed in obesity-associated end-organs or systems, such as adipose tissue, nerve system, cardiovascular system, liver and renal, and the change in their expressions and/or activities occurs in pathological obesity model (3). Here, P2RY2 is linked to obesity due to melanocortin 4 receptor deficiency.