P2Y2R deficiency has been reported to alleviate NAFLD by regulating liver lipid metabolism by reducing the levels of aspartate aminotransferase, alanine aminotransferase, and fatty acid synthesis mediators including differentiated CD36 clusters, stearoyl-CoA desaturase 1 and fatty acid synthetase (21). Here, P2RY2 is linked to metabolic dysfunction-associated steatotic liver disease.