OPG/RANKL/RANK is one of the most significant signaling pathways in the development of osteoporosis: osteoprotegerin (OPG), a factor secreted by osteoblasts, and a receptor activator of NF-κB ligand (RANKL) competitively bind to the receptor activator of NF-κB (RANK) (Wang F. et al., 2022). The gene discussed is TNFRSF11B; the disease is osteoporosis.