The vesicular glutamate transporter VGLUT1 is highly expressed in the granule cell layer of the human cerebellar cortex and reduced VGLUT1 expression has been reported in several cerebellar ataxia animal models (Tempia et al., 2015; Vigneault et al., 2015; Lin et al., 2017). The gene discussed is SLC17A7; the disease is aceruloplasminemia.