Notably, copper metabolism MURR1 domain 10 (COMMD10) is a critical protein in the regulation of radioresistance in HCC, which causes copper aggregation, thereby upregulating the expression of CP and SLC7A11 target genes, reducing lipid peroxidation levels, and inhibiting ferroptosis in HCC (82). The gene discussed is SLC7A11; the disease is hepatocellular carcinoma.