Researches have shown that copper can affect tumor angiogenesis by affecting HIF-1 (87); participat in tumor proliferation through the transcription factor ATOX1 (21), CCO (88) and MEK1 (89); regulate the Mediator of Cell Mobility protein (MEMO) (90), the Secreted Protein Acidic and Rich in Cysteine (SPARC) (91, 92), the copper binding enzymes LOX (93), to influence tumor spreading. Here, HIF1A is linked to neoplasm.