Non-tumor tissue of primary tumor patients (colon/rectum), with average methylation of 14.02% (ranging from 2.09 to 24.92) (N=5) had almost five times higher GRIA4 methylation status compared to non-tumor tissue of metastatic patients (liver), ranging from 1.44% to 4.87% (average 2.93%) (Supplementary Table S3), p= 0.012. This evidence concerns the gene GRIA4 and neoplasm.