Comparatively, the miR-126 is associated with leukemia stem cell maintenance (35), miR-17 promotes leukemia proliferation by targeting p21 (36), over-expression of miR-106 and miR-222 will promote CML proliferation (37), and miR-92a-1-5p inhibits TKI-induced necroptosis by targeting MLKL (38). This evidence concerns the gene MLKL and leukemia.