WWTR1 and neoplasm: On the contrary, SCC cells with high YAP-1 activity show deceased cell growth, increased apoptosis, and decreased migration with YAP-1 siRNA knockdown experiments (84, 85).Similarly, in orthotopic xenograft trials in which SCC cells were injected into the tongue of nude mice, shRNA suppression of YAP-1/TAZ lowered primary tumor volume and nearly eliminated metastasis formation after 22 days.