YAP1 and squamous cell carcinoma: Other squamous tumors with significant YAP-1 overexpression relative to the adjacent normal surrounding mucosa include cervical SCC (20) and head and neck squamous cancers (72–74) In light of the association between abnormal YAP-1 expression and tumor formation, it has been hypothesized that inhibiting YAP-1 may prevent the development or progression of squamous cell carcinoma (SCC) (63).