Mutations in chromatin remodeling genes are frequently reported (SMARC1, SMARCA2, ARID1A, ARID1B, CREBBP, EP300), and this class of genes has also been shown to be downregulated in ACC (SMARCA4, SMARCB1, SMARCC1, SMARCC2, ARID1, and PBRM1) (64, 71, 73, 74). This evidence concerns the gene EP300 and adrenal cortex carcinoma.