Even epigenetic changes are involved in this tumor biology, such as key mutations in chromatin remodeling (MERC1, SMARCA2, ARID1A, ARID1B, SMARCA4) and an imbalance in miRNAs (miR-155, miR-320a, miR-99a, miR-205) that regulate gene expression. The gene discussed is SMARCA4; the disease is neoplasm.