PRMT1 and central nervous system cancer: While altered histone methylation in IDH1-R132H gliomas is reported, there is a limited understanding of PRMT1, an arginine methyltransferase that regulates transcriptional activation of genes involved in gliomagenesis and cell death pathways by modulating its asymmetric dimethyl H4R3 epigenetic mark (H4R3me2a).