These cells also exhibit characteristic features of clonal hematopoiesis (CH), such as loss of DNA methyltransferase 3A (DNMT3A) and Tet methylcytosine dioxygenase 2 (TET2) with concurrent increase in the expression of janus kinase-2 (Jak2; these three gene products, and few others, are often termed as CH drivers). The gene discussed is JAK2; the disease is cyclic hematopoiesis.