Importantly, unlike Tie2 deletion, Tie1 deletion did not affect Vcam1 expression, and it decreased the expression of Clu and Fbln5 (Extended Data Fig. 9g and Supplementary Data 7; compare with Fig. 4b), suggesting that Tie1 and Tie2 have opposite effects on inflammatory responses involved in atherosclerosis. This evidence concerns the gene FBLN5 and atherosclerosis.