Importantly, the C allele conferred reduced risk of CAD (Effect size: -0.0278) and was associated with increased expression of TIE2. HyPrColoc analysis further demonstrated significant colocalization (posterior probability of 0.8789) between the GWAS and expression quantitative trait loci (eQTL) signals, supporting sharing of the same causal variant rs1322052. Here, TEK is linked to coronary artery disorder.