TEK and cardiovascular disorder: However, because the large sample sizes in genome-wide association studies (GWAS) improve candidate gene discovery for common diseases such as coronary artery disease (CAD), we took advantage of a meta-analysis of multiple GWAS23–27 from approximately 1.5 million individuals provided by the Cardiovascular Disease Knowledge Portal (broadcvdi.org, 2021 11/30) to examine the association of variants of the TIE2 gene with cardiovascular disease and related traits.