Collectively, our data indicate that an organ-specific vascular inflammatory response in the aorta is an important contributor to the increased atherosclerosis after arterial Tie2 or Tie1 plus Tie2 deletion (Fig. 7b), and that of these two receptors, Tie2 is the dominant receptor that counteracts inflammation and atherosclerosis in part via modulation of Foxo1 subcellular localization. This evidence concerns the gene FOXO1 and atherosclerosis.