HSPG2 and hepatocellular carcinoma: After 48 h of incubation, the transmembrane cell numbers of HCC-LM3 and PLC in the three RNAi groups vs. the NC group were 58 ± 18, 83 ± 24, 84 ± 13 vs. 154 ± 20 for HCC-LM3 (P = 0.0001, 0.0020, 0.0006) and 26 ± 7, 21 ± 8, 26 ± 7 vs. 57 ± 8 for PLC (P = 0.0074, 0.0050, 0.0070).