Interleukin-6 (IL-6) is a multifunctional cytokine that participates in multiple biological activities, such as cell proliferation, invasion, and angiogenesis10; it is also involved in epithelial-mesenchymal transformation (EMT) and promotes cell metastasis in HCC, which is correlated with the upregulation of IL‐6 expression. This evidence concerns the gene IL6 and hepatocellular carcinoma.