MMP23B and cancer: The results of overexpressing and silencing lnc-MMP2-2 in human brain microvascular endothelial cells (HBMECs) further identifies that lnc-MMP2-2 can impair tight junctions between HBMECs and induce EMT, resulting in the increased permeability of blood-brain barrier (BBB) and thus, enabling cancer cells in circulating system to penetrate into the brain 96.