TGFB1 and non-small cell lung carcinoma: lnc-MMP2-2 contained in TGF-β-mediated exosomes promotes the invasion and migration of NSCLC by regulating MMP2 expression, and enhances the brain metastasis of NSCLC by increasing BBB permeability, suggesting that exosomal lnc-MMP2-2 may be a novel therapeutic target for NSCLC treatment 91, 96.