In accordance with bioinformatics analysis that indicated lnc-MMP2-2 as a positive regulator of target gene expression at transcriptional level, exosomal lnc-MMP2-2 may facilitate the progression of NSCLC by activating the expression of its upstream gene MMP2 which is positively correlated with invasion and vascular permeability of lung cancer when entering recipient cells 91-95. This evidence concerns the gene MMP23B and lung carcinoma.