Zang et al. indicate that serum-derived exosomes isolated from NSCLC patients contain the markedly high levels of UFC1, which is one of several specific lncRNAs responsible for recruiting EZH2 histone methyltransferase to silence gene expression in an epigenetically modified manner, resulting in the repressed expression of PTEN and the activated Akt signaling pathway, thereby enhancing NSCLC cell proliferation, cell cycle arrest, invasion and migration, and inhibiting apoptosis 86. This evidence concerns the gene PRDM9 and non-small cell lung carcinoma.