According to ROC analysis, the AUC of exosomal lncRNA SNHG15 used alone for differentiating NSCLC from normal controls is 0.856, while the AUC of exosomal lncRNA SNHG15 combined with CEA for early diagnosis of NSCLC increases to 0.915. This evidence concerns the gene CEACAM5 and non-small cell lung carcinoma.