Peripheral blood-derived exosomes isolated from NSCLC patients with bone metastasis contain high levels of SOX2 overlapping transcript (SOX2-OT), which is closely related to poor overall survival and can promote bone metastasis in NSCLC by increasing the expression of RAC1 via targeting miR-194-5p 97. This evidence concerns the gene SOX2 and non-small cell lung carcinoma.