In contrast with circulating CYFRA21-1, a serum marker for NSCLC, circulating DLX6-AS1 has higher sensitivity and specificity in NSCLC diagnosis through ROC curve analysis, and the AUC of circulating DLX6-AS1 and CYFRA21-1 are 0.806 and 0.600, respectively. The gene discussed is DLX6; the disease is non-small cell lung carcinoma.