They further prove that exosomes secreted by NSCLC cells contain reduced levels of lncRNA growth arrest specific 5 (GAS5), which upregulates the expression of key lung cancer angiogenesis protein PTEN by binding to miRNA-29-3p and inhibits the PI3K/AKT signaling pathway of HUVECs, thus exerting its anti-angiogenesis effect on HUVECs 104-106. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.