In addition, tumor cell-derived exosomal SOX2-OT can also be transferred into macrophages and facilitate M2 macrophage polarization and repress M1 polarization by sponging miR-627-3p to upregulate Smads expression, ultimately enhancing EGFR-TKIs resistance in NSCLC 121. Here, SOX2 is linked to non-small cell lung carcinoma.