SACK1F and goiter: These researchers examined the expression of FAM83F protein in 106 cases of PTC, 34 cases of goiter and 41 cases of para-cancerous non-neoplastic thyroid tissues and found that 71% (76/106) of the PTC tissues showed overexpression of FAM83F protein in the cytoplasm, while the goiter tissue displayed overexpression of FAM83F protein in the nuclear tissue; however, FAM83F protein was not expressed in normal thyroid tissue 60.