FOXP3 and colorectal carcinoma: In line with the mRNA expression, high tumoural cytoplasmic S100A2 expression was significantly associated with an increase number of CD3+FOXP3+ cells as higher influx of T lymphocytes indicates a favourable prognosis in CRC and that high cytoplasmic S100A2 showed a better outcome in our cohort, however there is conflicting evidence regarding the influence of the regulatory subset of T cells in CRC 40-42.