The downregulation of ALDH6A1 in tumor tissues (P = 1.61×10-5) (Fig. 5C) and the marginally better overall survival of male HNSC patients with high ALDH6A1 level than females with low ALDH6A1 level (P = 9.8×10-2, Fig. 5D) suggest that ALDH2 and ALDH6A1 may contribute to differences in ALDH2 expression between normal and tumor tissues and survival in HNSC. The gene discussed is ALDH2; the disease is neoplasm.