However, the association is somehow contradictory to other studies that show increased ALDH2 enzymatic activity can enhance chemoresistance in specific contexts, such as with doxorubicin in renal cells 13 and microtubule inhibitors in lung cancers 14, suggesting the importance of considering the particular condition when studying the role of ALDH2 in drug resistance. The gene discussed is ALDH2; the disease is lung cancer.