Supporting this, Jun's team declared that TAGLN2-/- DCs exhibited significant defects in their abilities to home to draining lymph nodes(LNs) and to form optimal contacts with cognate CD4+ T cells to prime T cells, and these changes were associated with a failure to suppress tumor growth and metastasis of B16F10 melanoma cells in mice10. The gene discussed is TAGLN2; the disease is melanoma.