TAGLN2 and cancer: At the same time, we also found a positive correlation between TAGLN2 and cancer-associated fibroblasts in most tumors examined, cancer-associated fibroblasts within the TME have been shown to play several roles in the development of a tumor, including the secretion of growth factors, inflammatory ligands, and extracellular matrix proteins that stimulate cancer cell proliferation, therapy resistance, and immune exclusion51.