TAGLN2 and neoplasm: We proceeded to perform paired differential expression analysis of TAGLN2 between tumor and normal tissues within TCGA and discovered that TAGLN2 was upregulated in BLCA, BRCA, CHOL, COAD, ESCA, HNSC, KIRC, KIRP, LIHC, READ, STAD, UCEC, and THCA when compared to their matched normal samples (Figure 2F), and decreased expression in PRAD and KICH was further confirmed (Figure 2G).