Another anti-fibrotic gene repressed by EZH2 is peroxisome proliferator-activated receptor gamma (PPARγ) (Deng et al., 2012), a ligand-activated transcription factor that is linked to promoting protective effects against lung, cardiac, kidney, and liver fibrosis (Kokeny et al., 2020; Wu et al., 2020; Han et al., 2021). The gene discussed is PPARG; the disease is Hepatic fibrosis.