In three independent studies using mouse models of liver fibrosis, loss of EZH1 and EZH2 function led to the activation of fibrosis-related genes and the development or worsening of liver fibrosis (Bae et al., 2015; Grindheim et al., 2019; Lau-Corona et al., 2020). Here, EZH2 is linked to Hepatic fibrosis.