EZH2 and idiopathic pulmonary fibrosis: It was discovered in fibroblasts derived from the lungs of idiopathic fibrosis (IPF) patients that EZH2 leads to the tri-methylation of H3K27 and G9a tri-methylates H3K9, leading to condensed chromatin structure on the COX-2 promoter (Coward et al., 2014).