Two inhibitors of EZH2 HMT activity, 3-Deazaneplanocin A (DZNep) and GSK126, can preserve Smad7 expression to significantly prevent UUO-induced kidney fibrosis, transverse aortic constriction surgery-induced cardiac fibrosis in mice, and a mouse model of peritoneal fibrosis (Zhou et al., 2016; Shi et al., 2020; Ge et al., 2022). The gene discussed is SMAD7; the disease is Peritoneal Fibrosis.