Moreover, blocking EZH2 with DZNeP was able to upregulate Smad 7 expression, downregulate TGFβ signaling, and abrogate an EMT response associated with pulmonary fibrosis both in an in vivo LPS-induced acute respiratory distress syndrome-associated pulmonary fibrosis mouse model and in an in vitro model involving lung epithelial cells (Bao et al., 2021). Here, TGFB1 is linked to pulmonary fibrosis.