GARS1 and cancer: M1 macrophages exert anti-tumor activity in cancer environment, and could be induced by miRNA-33- and miRNA-130-overexpressing EVs (Moradi-Chaleshtori et al., 2021) as well as by macrophage-derived EVs expressing human glycyl-tRNA synthetase-1 that trigger cancer cell death (Park et al., 2022).