TNF and colitis: More severe forms of colitis may require treatment with steroids, usually given in a taper over four to six weeks, gastroenterology consultation with esophagogastroduodenoscopy (EGD) and colonoscopy, and other agents such as infliximab or other anti-tumor necrosis factors (anti-TNF therapies) when no response to corticosteroids occurs after 48 to 72 hours [7].