A comparison of other major EMT markers between PC3 and PC-3M revealed EZH2, Snail/SNAI1, Slug/SNAI2, and TWIST1, were expressed highly in PC-3M compared with PC-3, yet both are ARLow/mCRPC/NEPC prostate cancer subtypes (Fig. 5A). Here, EZH2 is linked to Familial prostate cancer.