CXCL8 and Familial prostate cancer: Furthermore, oxidative phosphorylation, p70S6K, unfolded response, TREM1, NFκB, ERK5, IL8, BAG2, Integrin, and VEGF signaling were identified (z score 5.574 to −4.811) as top canonical pathways for ARLow/mCRPC/NEPC prostate cancer (Supplementary Fig. S2B).